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Search Results for " tgf-β type ii receptor "

3

抑制剂 & 化合物

1

化合物库

8

重组蛋白

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Cat. No.	Product Name
L4100	TGF-β/Smad靶点化合物库		184 compounds
	184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

TGF-β/Smad靶点化合物库

Cat.No: L4100

Compounds: 184

Cat. No.	Product Name	Target	Signaling Pathways
T24612	Pentachloropseudilin PClP
	Pentachloropseudilin is a selective inhibitor of Myosin-1. In target cells, It acts by suppressing transforming growth factor-β activity by accelerating cell-surface type II TGF-β receptor turnover.
T2123	LY2109761	Autophagy; TGF-beta/Smad	Autophagy; Stem Cells
	LY2109761 是一种新型选择性 TGF-β 受体 I/II 型 (TβRI/II) 双重抑制剂，Ki 分别为 38 nM 和 300 nM。
T1800	GW788388 GW 788388	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	GW788388 是一种 ALK5抑制剂(IC50:18 nM)。它也抑制 TGF-β II 型受体和激活素 II 型受体的活性，但对 BMP II 型受体无影响。

化合物

Pentachloropseudilin

Cat.No: T24612

Synonym: PClP

Cat.No: T2123

Target: Autophagy, TGF-beta/Smad

Cat.No: T1800

Synonym: GW 788388

Target: ALK, TGF-beta/Smad

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00335	TGFBR2 Protein, Mouse, Recombinant (His) TGFR-2,TGF-beta type II ...	Mouse	HEK293 Cells
	TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
TMPJ-00333	TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc) Transforming growth factor-β receptor ...	Mouse	HEK293 Cells
	TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-75 KDa and the accession number is Q62312.
TMPJ-00334	TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) TGF-β receptor type ...	Mouse	HEK293 Cells
	TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-65 KDa and the accession number is Q62312-2.
TMPJ-01178	TGFBR1 Protein, Mouse, Recombinant (hFc) ALK-5,ALK-5ALK5,TGFβRI,tβR-I,LDS1...	Mouse	HEK293 Cells
	TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i...
TMPJ-00261	TGF beta 2 Protein, Mouse/Rat, Recombinant transforming growth factor β-2,BSC-1 cell growth in...	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n...
TMPJ-00254	TGF beta 3 Protein, Human/Mouse/Rat, Recombinant Latency-associated peptide,TGF-beta-3,Transforming ...	Human,Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regu...
TMPJ-00771	TGF beta 1 Protein, Mouse/Rat, Recombinant TGFB,TGFbeta,CEDLAP,TGF-beta-1,	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)...
TMPJ-00314	ACVR2B Protein, Human, Recombinant (hFc & His) ACVR2B,Activin Receptor Type IIB,...	Human	HEK293 Cells
	Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, ...

重组蛋白

TGFBR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00335

Species: Mouse

Expression System: HEK293 Cells

TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)

Cat.No: TMPJ-00333

Species: Mouse

Expression System: HEK293 Cells

TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)

Cat.No: TMPJ-00334

Species: Mouse

Expression System: HEK293 Cells

TGFBR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01178

Species: Mouse

Expression System: HEK293 Cells

TGF beta 2 Protein, Mouse/Rat, Recombinant

Cat.No: TMPJ-00261

Species: Mouse,Rat

Expression System: HEK293 Cells

TGF beta 3 Protein, Human/Mouse/Rat, Recombinant

Cat.No: TMPJ-00254

Species: Human,Mouse,Rat

Expression System: HEK293 Cells

TGF beta 1 Protein, Mouse/Rat, Recombinant

Cat.No: TMPJ-00771

Species: Mouse,Rat

Expression System: HEK293 Cells

ACVR2B Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00314

Species: Human

Expression System: HEK293 Cells

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